Aim
To define the molecular mechanisms of viral disease and translate them into therapeutic strategies that target both the virus and its consequences for the host.
Laboratory of Epigenetics of Viral Infections, Duke-NUS
What a respiratory virus changes inside our cells, and what it leaves behind
We study how influenza A virus, SARS-CoV-2 and other respiratory viruses reprogram the cells they infect, and how those changes shape the course of infection and recovery.
Host cell Infected Goblet cell
The lab
Two layers of host gene regulation
Our work focuses on two layers of gene regulation that respiratory virus infection remodels: RNA processing, which determines which transcripts and proteins a cell produces, and the epigenome, which governs how genes are regulated during infection and after it has resolved.
Mission
To understand how infection changes the way the host genome is read, and which of these changes are restored, or retained, as the tissue recovers.
Join the lab
We welcome enquiries from researchers with interests in virology, RNA biology, chromatin and genomics.
PhD students
Doctoral projects within the RNA processing and epigenome programmes.
Postdoctoral fellows
Independent projects combining infection models with long-read and multi-omic approaches.
Visiting scientists
Research stays and collaborations, by arrangement.